Wednesday, October 10, 2012

Albert Einstein's Brain

Albert Einstein's brain has often been a subject of research and speculation. It was removed within seven and a half hours of his death. The brain has attracted attention because of Einstein's reputation for being one of the foremost geniuses of the 20th century, and apparent regularities or irregularities in the brain have been used to support various ideas about correlations in neuroanatomy with general or mathematical intelligence. Scientific studies have suggested that regions involved in speech and language are smaller, while regions involved with numerical and spatial processing are larger. Other studies have suggested an increased number of Glial cells in Einstein's brain



Preservation

Einstein's autopsy was conducted in a lab at the University of Pennsylvania by pathologist Thomas Stoltz Harvey at Princeton shortly after his death. Harvey then removed, weighed and dissected Einstein's brain into several pieces; some of the pieces he kept to himself while others were given to leading pathologists. He claimed he hoped that cytoarchitectonics would reveal useful information. Harvey injected 10% formalin through the internal carotid arteries and afterwards suspended the intact brain in 10% formalin. Harvey photographed the brain from many angles. He then dissected it into about 240 blocks (each about 1 cm3) and encased the segments in a plastic-like material called collodion. Harvey also removed Einstein's eyes, and gave them to Henry Abrams.

Harvey noticed immediately that Einstein had no parietal operculum in either hemisphere. Photographs of the brain show an enlarged Sylvian fissure; clearly Einstein's brain grew in an interesting way. In 1999, further analysis by a team at McMaster University in Hamilton, Ontario, Canada revealed that his parietal operculum region in the inferior frontal gyrus in the frontal lobe of the brain was vacant. Also absent was part of a bordering region called thelateral sulcus (Sylvian fissure). Researchers at McMaster University speculated that the vacancy may have enabled neurons in this part of his brain to communicate better. "This unusual brain anatomy...(missing part of the Sylvian fissure)... may explain why Einstein thought the way he did," said Professor SandraWitelson who led the research published in The Lancet. This study was based on photographs of Einstein's brain made in 1955 by Dr. Harvey, and not direct examination of the brain. Einstein himself claimed that he thought visually rather than verbally. Professor Laurie Hall of Cambridge University commenting on the study, said, "To say there is a definite link is one bridge too far, at the moment. So far the case isn't proven. But magnetic resonance and other new technologies are allowing us to start to probe those very questions".
Scientists are currently interested in the possibility that physical differences in brain structure could determine different abilities. One part of the operculum called Broca's area plays an important role in speech production. To compensate, the inferior parietal lobe was 15 percent wider than normal.The inferior parietal region is responsible for mathematical thought, visuospatial cognition, and imagery of movement.


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